Projektnummer

0050230

Zusammenfassung

This research project focuses on the application of principles of noise-induced phenomena to a complex molecular machine, the proteasome, and on the investigation of its activity control for medical purposes. The modeling methodology assumes a constructive role of fluctuations, provided by internal stochasticity or external influence. The aim is to develop a stochastic model of the proteasom and to shed light on the nature of directed transport of proteins in the proteasome and on mechanisms regulating the size of the proteasome products. This may lead to new concepts for the treatment...