Projektnummer

0050251

Zusammenfassung

The proposed work combines methods from molecular simulations and statistical physics for the modelling of the dynamic assembly and disassembly of large supra-molecular complexes in biological systems. Identification of such complexes has recently become a central issue of proteomics research. Hereby, various processes occur on a multitude of time-scales from nanoseconds (formation of individual protein-protein complexes) to seconds (formation of entire supra-molecular complexes). While standard molecular simulation techniques are not capable of bridging these vastly different time sc...