Projektnummer

0050325

Zusammenfassung

The ubiquitous phenomenon of cell spreading and migration on an adhesive substrate is a challenging research topic in molecular and cellular biomechanics with relevant biomedical applications. During the last ten years new experimental techniques have been developed and applied, allowing to formulate specific hypotheses about essential biochemical ingredients and biophysical mechanisms that induce cell-substrate adhesion, cell shape deformation and subsequent translocation. Two of the essential components are the diverse family of integrins, trans-membrane proteins responsible for atta...