Projektnummer

0050486

Zusammenfassung

Pavlovian fear conditioning is one of the most powerful paradigms to study emotional learning. Activity-dependent changes of neuronal connections in the form of long-term potentiation (LTP) in the amygdala might underlie fear conditioning as suggested by numerous behavioural and in vivo electrophysiological experiments. However, molecular mechanisms modulating synaptic transmission in the amygdala are not understood. By using mouse mutants with gene-targeted deletions of AMPA receptor subtypes - the principal glutamate-gated ion channels for fast synaptic transmission in the brain - pr...