Projektnummer

0050550

Zusammenfassung

Cytoplasmatic proteins involved in signal transduction are commonly constructed of modular domains which either have a catalytic function (e.g. kinases) or belong to the protein interaction domains (PIDs). The latter play a critical role in the assembly of protein complexes which control the complex cellular behaviour. One PID of great interest is the PDZ domain, a 100 amino-acid-residue domain. It frequently occurs as multiple copies in cytoplasmatic proteins and is often involved in the assembly of molecular complexes near the plasma membrane. While most PDZ domains recognize short, ...