Projektdatenbank (ab 2004)

Projektnummer

0050862

Zusammenfassung

Immunological memory, defined as faster and more vigorous responses of an antigen-primed host, may protect from diseases of which the host has recovered before. However, it also bears the risk to create immunopathology and autoimmunity. It is maintained by long-lived memory B and T cells that differentiate from naïve precursor cells upon antigen exposure. Aim of the professorship is a molecular understanding of the cellular differentiation pathways and inductive signals for memory cell generation, i.e., the relationship between the generation of effector cells and memory cells and whether and ...