Projektnummer

0051084

Zusammenfassung

Filarial infections belong to the major diseases in sub-Saharan Africa and are strongly associated with poverty. At present, WHO-led control activities in Africa mainly rely on mass administration of micro- filaricidal drugs, with quite some success. However, it has become clear that new, complementary therapies must be developed for sustain- able control. Depletion of Wolbachia essential endosymbionts of filariae with doxycycline resulted in macrofilaricidal activity in lymphatic filariasis (LF) and in long-term-sterilizing activity of adult female worms in onchocerciasis. In this pro...