Projektnummer

0051366

Zusammenfassung

Transforming growth factor beta (TGF-beta)-type signaling underlies most tumorigenesis events and regulates embryonic development by providing positional information to cells. In recent years much has been discovered about the molecular and biochemical features of the TGF-beta signal transduction machineries, the conformational changes of the components of that machinery during signaling, the role of TGF-beta signaling in many developmental contexts, and the involvement of anomalous TGF-beta signaling in many diseases, including cancer. In contrast, investigation of the cell biology of...