Projektnummer

0051404

Zusammenfassung

The NADH:ubiquinone oxidoreductase, also called respiratory complex I, couples the transfer of electrons from NADH to ubiquinone with the translocation of protons across the membrane. Its mechanism is largely unknown due to its complicated composition. Its dysfunction is connected to many neurodegenerative diseases such as Parkinson's disease. NADH- but not NADPH-binding induces long-range conformational changes extending to more than 190 Å. They lead to the opening of the ubiquinone binding site inducing the active conformation of the complex. In this project the aim is to determine t...