Projektnummer

0051420

Zusammenfassung

Pre-mRNA splicing is carried out by an elaborate ribonucleoprotein (RNP) complex, the spliceosome, which is assembled anew on each pre-mRNA intron by the stepwise interaction of snRNPs and multiple non-snRNP splicing factors. During its maturation into a catalytically active RNP, the spliceosome is repeatedly remodeled, undergoing multiple compositional and conformational changes. At present, only a limited number of spliceosome assembly/maturation intermediates can be distinguished, and they appear to represent a mixture of RNP conformational states. The specific inhibition of spliceo...