Projektnummer

0051861

Zusammenfassung

Materials scientists can learn a great deal from the mechanisms whereby cells construct their own environment. Recent studies have shown that cell-matrix interaction is regulated not only by the specific multi-protein composition of the matrix but also by its mechanical properties. These studies demonstrated that adhesion-mediated signaling and the subsequent molecular interactions at the cytoplasmic faces of adhesion sites can be switched on or off by mechanical stress. The mechanisms underlying the transduction of mechanochemical and structural information via the protein networks of...