Projektnummer

0051938

Zusammenfassung

Evolutionary processes of host-pathogen interaction considerably shape the genomes of both organisms, favouring the development of resistance genes (host) and of immune escape mechanisms (pathogen). Notably, retroviruses impact the evolution of the vertebrate immune system. Retroviruses encounter dominant postentry restrictions in cells of particular species Human immunodeficiency virus (HIV-1) for example is blocked by TRIM5alpha, a tripartite motif (TRIM) protein, in cells of Old World monkeys. Rhesus monkey TRIM5alpha more potently blocks HIV-1 infection than human TRIM5alpha. Rece...