Projektdatenbank (ab 2004)

Projektnummer

0052135

Zusammenfassung

Mechanical forces play an important role in the regulation of cell ad- hesion and migration during chemotaxis. These processes rely on in- tegrin force signalling mediated by cellular adhesion to extracellular matrix components and modulation by chemoattractant growth factors. Focal adhesion kinase (FAK) is situated in a key position, integrating both the integrin and growth factor receptor signalling pathways. In order to explore the molecular mechanism by which forces are trans- duced into cellular signals optical biosensors will be designed and implemented reporting on force-induced...