Projektnummer

0052277

Zusammenfassung

Proper folding of proteins often is achieved with the help of so-called molecular chaperones. Chemical chaperones are synthetic small molecules which can exhibit similar functions to specific target proteins. They have raised vivid attention in connection with lysosomal storage disorders which result from genetic defects of the genes for lysosomal lipid hydrolases. Reduced enzyme activity is often a result of protein misfolding right after synthesis. A rational approach to chemical chaperones is the synthesis of substrate-analogues or competitive inhibitors binding to the active site ...