Projektnummer

0052305

Zusammenfassung

Tau is a neuronal protein important for microtubule stabilization during axonal growth and brain development. The protein is structurally unusual in that it adopts a "natively unfolded" state. In human brain tissue, tau can aggregate into "paired helical filaments" (PHF) which represent a hallmark of Alzheimer's disease and related neurodegenerative "tauopathies". It is proposed to analyze the structure of tau by NMR-based methods, identify different conformations on the way from the soluble monomer to the insoluble fibril that underlie the pathological aggregation. It is planned to s...