Projektnummer

0052438

Zusammenfassung

Protein-protein interactions play an important role in signal transduction controlling both physiological and pathophysiological processes. Thus, interacting interfaces of protein complexes are attractive targets for chemical compounds serving both therapeutic and diagnostic purposes. Alpha-helical peptidomimetics based on terphenyl scaffolds have been demonstrated to tightly and specifically bind to protein counterparts and to interfere with protein-protein interactions. The aim of this project is the preparation and detailed analysis of terphenyl derivatives as conformation-dependent...