Projektnummer

0052492

Zusammenfassung

The causative role of the human major histocompatibility gene HLA-B27 in spondyloarthropathies, a common group of chronic inflammatory rheumatic diseases, is not understood, but the HLA-B27 molecule itself appears as the strongest predisposing factor for pathogenesis. It seems that the study of HLA-B27 subtypes differing at only one amino acid position might provide a clue to pathogenesis. It is proposed to investigate the peptide dynamics and conformational changes in a comparative study with the two differentially disease associated subtypes B*2705 and B*2709, complexed with three se...