Projektnummer

0052514

Zusammenfassung

The aim of the project is to examine the evolutionary origin of the biosynthetic pathway of the diterpenoide natural product Taxol. In this context the focus lies on the investigation of gene transfer processes between evolutionary distantly related species. Therefore, the production of Taxol in plants, Taxus spp., as well as in endophytic fungi like Taxomyces andreanae, an endophyte isolated from the inner bark of the pacific yew Taxus brevifolia, provides an excellent model system. Through identification and characterisation of the biosynthetic genes from Taxomyces andreanae and foll...