Projektnummer

0052558

Zusammenfassung

Vacuolar type ATPases (V-ATPases) are heteromultimeric, proton translocating membrane proteins which energize many different transport processes. As their functionality is correlated with various diseases such as renal acidosis or cancer, the development and molecular understanding of selective and synthetically accessible inhibitors present highly desirable research goals. The polyketide natural products archazolid A and B constitute novel types of particularly efficient and specific inhibitors of V-ATPases, both in vitro and in vivo. Based on the results of the pilot project detailed...