Projektnummer

0053781

Zusammenfassung

Miniaturization of biochemical and pharmaceutical assays to an ultimate level of sensitivity is a prerequisite to study interactions and activities of single molecules at physiological concentrations in a highly paralleled format. In this project a combined top-down and bottom-up strategy is proposed to overcome the fundamental gap between the nanomolar concentration regime of current optical single-molecule spectroscopy techniques and the nano- to millimolar dissociation constants of typical biomolecular interactions. With the help of a recently developed "cut and paste" technology si...