Projektnummer

0054551

Zusammenfassung

The thematic scope covers the functional interaction between the circadian timing system and metabolic homeostasis, a topic at the border between physiology, endocrinology, and diabetology, relying heavily on mouse genetics, molecular biology, and life imaging techniques. A tight interaction between circadian and metabolic regulation has been described in both human and animal studies. Clock disruption severely affects metabolic homeostasis and promotes the development of obesity-associated disorders such as type II diabetes and the metabolic syndrome. So far, however, little is known ...