Projektnummer

0054672

Zusammenfassung

Continued success of onchocerciasis control and elimination programmes worldwide is largely dependent on the sustained efficacy of ivermectin (IVM), which remains the only drug available for the control of the disease. However, recent reports show sub-optimal responses to ivermectin treatment and evidence of genetic selection in Onchocerca volvulus, raising concerns about the possible emergence of IVM resistance. Since IVM resistance is suggested to be polygenic, genetic analysis will be carried out on another candidate gene, gamma amino butyric acid (GABA) receptor HG1, known to be in...