Projektdatenbank (ab 2004)

Projektnummer

0055289

Zusammenfassung

Polyketide synthases (PKS) and fatty acid synthases (FAS) belong to the same protein family. Both are multistep enzymes, and both catalyze reactions by a similar working concept. However, as compared to FAS, PKS show variations in their functional spectrum, and their products, termed polyketides, are of more complex chemistry than fatty acids. Polyketides are produced by many microorganisms to mediate a growth advantage by being toxic to other (micro)organisms in the same habitat. This intrinsic high bioactivity of polyketides has been used in medicine for decades to target acute and d...