Projektnummer

0055585

Zusammenfassung

Recognition of numerous antigens is important for an effective and specific immune response. One way that a host can evolve diversity of immune recognition and effector molecules, is through alternative splicing. In this project I propose to examine whether the massively alternatively spliced putative immune receptor Down syndrome cell adhesion molecule, Dscam, could play a role in specific immune responses, at the phenotypic and the genotypic level. I will address the phenotype using a three-pronged approach using transcriptomics, protein and immune assay readout levels. Addressing Ds...