Projektnummer

0055764

Zusammenfassung

Due to the problem of resistency of many bacteria against common antibiotics, there is a strong need for the development of new chemical entities and their biological evaluation as new antimicrobial agents. The goal of the present project is to combine the structural features of pharmacologically active fluorinated N-heterocycles (indoles, purines, purine isosters, etc.) and amino acids and peptides. In this context, we will develop an efficient synthesis of enantiomerically pure heterocyclic fluorinated non-proteinogenic amino acids and their peptides which contain pharmacologically r...