Projektnummer

0055955

Zusammenfassung

When the rapidly increasing miniaturization of bio-molecular assays reached the single-molecule level, a new fundamental gap between the nanomolar concentration regime of current optical single-molecule spectroscopy techniques and the nano- to millimolar dissociation constants of typical bio-molecular interactions opened up. This gap will be addressed by placing individual molecules in the aperture of zero mode waveguides. Up to now, the focus was on the design and manufacturing of suitable waveguides, their surface functionalization and their specific optical properties. The data demo...