Projektnummer

0056620

Zusammenfassung

In the first phase we have successfully explored the use of an innovative heat application system to treat Mycobacterium ulcerans disease in a proof-of-principle study, confirmed the efficacy of heat treatment at the primary endpoint (six months after heat treatment) in a large GCP-conform trial, and studied the treatment-induced microbiological, histopathological and immunological evolution of BU lesions of relevance for the understanding of wound healing processes and clinical BU treatment management. We found strikingly heterogeneous treatment responses of BU lesions. Based on our ...