Projektnummer

0057172

Zusammenfassung

Alzheimer's disease (AD) is characterized by two primary neuropathological lesions, neurofibrillary tangles, and amyloid plaques. Neurofibrillary tangles are intracellular, filamentous aggregates of the neuronal protein tau in a hyperphosphorylated form. Amyloid plaques are extracellular aggregates of a peptide, amyloid ß protein (Aß), which is generated from the transmembrane domain of the amyloid precursor protein. Investigations on the temporal, functional and hierarchical relationship of the two neuropathological lesions have yielded surprisingly contradictory results. Discrepancie...