Projektdatenbank (ab 2004)

Projektnummer

0057528

Zusammenfassung

Life is not static, but most structural biology methods are since they require fixed samples. Since the majority of proteins needs to sample multiple conformations for their activity, structural biologists have either to repeatedly arrest the protein of interest in different conformations, or rely on secondary assays to infer information on protein dynamics. While the latter has the drawback that it is not straightforward to reconcile data from different sources, obtaining structures from each conformational state is also quite demanding. More so, as prior knowledge of the exact reacti...