Engineering binding cavities and surface amphiphilicity at the molecular scale for efficient in vivo drug delivery
Projektnummer
0057772
Zusammenfassung
Shape-persistent polyphenylene dendrimers (PPDs) with a chromophore core, varying am-phiphilic surface patterns and tuneable lipophilic inner cavities are achieved by rational design from tailored molecular building blocks. Adjustable inner lipophilic binding pockets allow the accommodation of various numbers of guest molecules, which is an important feature of natural transport proteins. The orientation, size and nature of the amphiphilic surface patterns have a distinct impact on solubility and aggregate formation of the resultant nanosized PPDs. We will unravel unique insights into ...
Projektinformationen
Status:
Beendet
Startdatum:
01.07.2014
Enddatum:
30.11.2017
Fördersumme:
511.200 €
Profilbereich:
Exploration
Förderinitiative:
Integration molekularer Komponenten in funktionale makroskopische Systeme