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Engineering binding cavities and surface amphiphilicity at the molecular scale for efficient in vivo drug delivery

Projektnummer

0057772

Zusammenfassung

Shape-persistent polyphenylene dendrimers (PPDs) with a chromophore core, varying am-phiphilic surface patterns and tuneable lipophilic inner cavities are achieved by rational design from tailored molecular building blocks. Adjustable inner lipophilic binding pockets allow the accommodation of various numbers of guest molecules, which is an important feature of natural transport proteins. The orientation, size and nature of the amphiphilic surface patterns have a distinct impact on solubility and aggregate formation of the resultant nanosized PPDs. We will unravel unique insights into ...

Projektinformationen

Status:

Beendet

Startdatum:

01.07.2014

Enddatum:

30.11.2017

Fördersumme:

511.200 €

Profilbereich:

Exploration

Förderinitiative:

Integration molekularer Komponenten in funktionale makroskopische Systeme