Projektdatenbank (ab 2004)

Projektnummer

0058033

Zusammenfassung

Human herpesvirus-6 (HHV-6) achieves latency by integrating into human genome. Can activation of integrated HHV-6 shorten telomeres and cause unstable telomeric ends that contribute to disease? Can activated, partial or full-length viral genome reintegrate into human chromosome or is it lost completely? Can latent or activated HHV-6 influence the host cell through partial transcription or translation? Preliminary data shows that chromosomally integrated HHV-6 is not always silent. Common drugs and environmental exposure can activate it. Whole or parts of viral genome can shuffle in and...