Projektdatenbank (ab 2004)

Projektnummer

0058642

Zusammenfassung

Despite recent technological progress, the understanding of the molecular complexity and intra-tumoral heterogeneity in hepatocellular carcinoma (HCC) remains limited. This lack of information represents a major challenge for both, preventive strategies as well as therapeutic approaches in HCC. The goal of the professorship is to define the multi-stage molecular evolution of HCC. First, the impact of preventive modulation of the tumor-microenvironment for liver cancer development will be tested. Therefore, inhibition of key pro-oncogenic factors such as insulin signaling, inflammation ...