Projektnummer

0059348

Zusammenfassung

Using biochemical, electrophysiological and in vivo/in situ imaging approaches the following specific aims will be adressed: 1) Characterization of the biochemical (energetic balance, efficiency of glycolysis and mitochondrial function, oxidative stress intensity) and physiological (at the single cell and network level) status of the ageing brain. 2) Comparison of the extent of ageing-induced deregulation of brain function in control and CR animals. 3) Deciphering cellular/molecular mechanisms underlying beneficial effects of CR, identification of pathways that can be targeted by CR-m...