Projektnummer

0059448

Zusammenfassung

The project aims to discover new drug targets for co-morbid diseases in humans using such frequently co-morbid pathologies as asthma and hypertension. A computer search will be carried out to fulfil the target. For genes for potential drug targets identified insilico, the probability of the effect of promoter single nucleotide polymorphisms (SNPs) on the efficiency of transcription factor binding will be estimated. The SNPs with highest possible functional effect will be further explored for their association with asthma, hypertension, and a combination of the diseases. To identify pat...