Projektnummer

0060516

Zusammenfassung

The central nervous system (CNS) does not recover from traumatic axonal injury while the peripheral nervous system (PNS) does. This difference in regenerative capacity might be based on an absence of stimulatory mechanical forces in the CNS, due to the protective rigidity of the vertebral column and skull. In this Experiment! it is postulated that the CNS has retained its capacity to respond to appropriate mechanical stimuli with enhanced regenerative capacity. To address this, low strain axonal stretch will be applied to a novel adult mouse dorsal root ganglion plus nerve explant mode...