Projektnummer

0062881

Zusammenfassung

It is unclear whether humans and closely-related large animal models like pigs can enter a low temperature, "hibernation-like" state. Recent progress has allowed the identification and manipulation of so called thermostat cells in the laboratory mouse and activation of these discrete hypothalamic neurons in vivo triggers a low-temperature state (down to 27°C body temperature) which is completely reversible. By pharmacologically manipulating the central thermostat in pig brains, the project aims to test whether it is possible to induce "hibernation-on-demand" in a large animal model. Fo...