Projektnummer

0064416

Zusammenfassung

A novel class of antibiotics and cytotoxins for the treatment of parasitic infections and malignant tumors Both tumor therapy and anti-parasitic therapy require that cytotoxic agents selectively kill abnormal or invaded cells while sparing healthy cells. In tumor therapy, the primary criterion for this distinction is the tumor cells' faster division, such that the mainstay of modern oncotherapy are agents that interfere with nucleotide biosynthesis, DNA integrity, cytokinesis, or mitogenic signaling. Moreover, it has been proposed that beyond these two principles, the often very diffe...