Projektdatenbank (ab 2004)

Projektnummer

0064501

Zusammenfassung

Intracellular pathogens are experts in immune evasion. Development of a protective immune response relies on induction of specific T-cell responses, which is best achieved with live attenuated vaccines. However, many of these pathogens are experimentally not accessible and attenuated strains (especially in case of the malaria-causing parasite Plasmodium) cannot be produced in huge amounts, are hard to preserve and to administer. Genetic modification of the intracellular parasite Toxoplasma gondii is straight forward and many virulence factors have been identified. The aim of this resea...