Projektdatenbank (ab 2004)

Projektnummer

0064739

Zusammenfassung

Small non-coding RNAs (sncRNAs) have been recognized as master regulators that are evolutionary conserved and have an impact on all essential physiological and pathological processes. In addition to their role as biomarkers, their potential as novel therapeutic agents is investigated. With increasing age of mammals, the repertoire of sncRNAs decreases significantly and yet increasing portion of these molecules has been correlated with healthy aging of humans older than 100 years. Animal experiments have shown that blood transfusions (from young individuals to older ones) have a positiv...