Projektnummer

0065840

Zusammenfassung

Among stem cells, which originate and maintain human life, hematopoietic stem cells give rise to all functional blood cells, including immune cells, and therefore are used for transplantation in the treatment of cancers and immune system disorders. As long-term ex vivo expansion of hematopoietic stem and progenitor cells (HSPCs) seems to be unattainable, there is an urgent need to identify methods to accomplish efficient progenitor cell expansion. Here the research group outlines the concept of using leukemia-associated engineered inducible transcription factors (iTFs) conferring susta...