Projektnummer

0066038

Zusammenfassung

IgE antibodies (Abs) mediate allergic reactions, including severe systemic anaphylaxis, by binding to the high-affinity IgE receptor on mast cells and basophils leading to release of inflammatory mediators. However, it is still not predictable why allergen-specific IgE Abs induce allergic reactions in some individuals but not in others. Furthermore, there is no reliable biomarker why some patients with allergic reactions to e.g. pollen develop chronic allergic conditions (asthma) over time and others not and why allergen-specific immunotherapy works in some patients but not in others. ...