Projektnummer

0066154

Zusammenfassung

Neurodegenerative diseases like Alzheimer's Disease, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis are characterized by pathological aggregation of neuronal proteins in the brain, but the loss of neuronal function seems to occur independent of protein aggregates and is caused by unknown mechanisms. As a novel concept to explain neurotoxicity in proteinopathies, this project proposes that proteinopathy proteins are directly linked to DNA damage and therefore contribute to genomic instability and neuronal death in these diseases. To test this hypothesis, a combination of gen...