Projektnummer

0066848

Zusammenfassung

The origin of the universal genetic code - one of the most important foundational problems in molecular biology - is still open. The stereochemical hypothesis proposes that the code evolved from nucleobase/amino-acid binding preferences, but direct evidence has been lacking. Recently, the research team has demonstrated that the nucleobase density profiles of mRNA coding sequences match the respective nucleobase affinity profiles of protein sequences they encode. This finding generalizes the stereochemical hypothesis to complete biopolymers and suggests that mRNAs and their cognate pro...