Projektnummer

0068160

Zusammenfassung

Anti-coronavirus therapeutics with new mechanisms of function are urgently needed to address the current SARS-Cov-2 pandemic and prepare for future coronavirus diseases. Within this project, first-in-class small molecules activating the OAS-RNase L pathway are to be identified to degrade viral RNA and accelerate viral clearance. The mechanism of RNA degradation via small-molecule OAS activators will be evaluated for the first time to develop therapeutic candidates.