Projektnummer

0069333

Zusammenfassung

Diseases can be caused by genomic mutations and can affect men and women differently, but even with advanced methods using induced pluripotent stem cells (iPSCs) the underlying mechanisms of sexual dimorphisms are hard to study in vitro because of the huge number of genetic variations that exist between individuals anyway. Therefore, this project aims to create pairs of iPSC lines that only differ in their sex chromosomes (XX or XY) but are otherwise identical, so that differentiated cell types (in this project heart muscle cells) can be directly compared, namely male cells with their ...