Projektnummer

0069378

Zusammenfassung

Infection by SARS-CoV-2, the causing agent of COVID-19, strictly depends on the interaction of the Spike protein with cellular receptors, most notably ACE2. Interfering with this interaction represents an important opportunity for therapy and prevention. The research team isolated and characterized the first Göttingen virus strain and has developed antibody fragments, termed nanobodies, from alpacas immunized with the Spike protein. The team found these nanobodies against the receptor-binding domain of Spike to neutralize the virus at low picomolar concentrations, revealing extraordinary poten...