Projektnummer

0069417

Zusammenfassung

Patients with COVID-19 develop a wide range of neurologic symptoms. These include severe neurological diseases such as encephalopathy, viral encephalitis and virus-mediated acute neurodegeneration in the brain stem directly causing respiratory failure. While neurotropism of coronaviridae has well been documented, the disease mechanisms of central nervous system infection of SARS-CoV-2 are not understood. The project's hypothesis is that neuronal infection with SARS-CoV-2 induces a neuronal stress response that can lead to programmed cell death in neurons and that SARS-CoV-2-induced ne...