Projektnummer

0069419

Zusammenfassung

Viruses belonging to the family of Coronaviridae, Togaviridae, and Hepeviridae contain genes that encode a conserved protein domain, referred to as macrodomain. However, the role of this domain during infection is in need of clarification. Mammalian macrodomain proteins remove enzymatically ADP-ribose, a common post-translational modification, from substrates. ADP-ribosylation is particularly relevant to activate vital stress signaling pathways, like e.g. during viral infection. Studies describing both the enzymatic activity and function of viral macrodomains have defined these domains...