Projektnummer

0069439

Zusammenfassung

The lack of medical treatment options is a major challenge during the current COVID-19 pandemic. SARS-CoV-2 is a newly emerged highly pathogenic zoonotic coronavirus, causing mild to severe respiratory symptoms but also embolisms, pneumonia, and neurological disease through enhanced inflammatory and autoimmune responses. The research team previously showed that human pathogenic CoVs limit autophagy, the cellular recycling system of cells involved in the inflammatory response, and found that compound-driven autophagy induction inhibits replication of highly pathogenic CoV. To generate i...