Projektnummer

0069444

Zusammenfassung

PROTACs (proteolysis targeting chimeras) represent a new type of therapeutic drugs. The novel principle is that target structures (proteins) are not only inhibited (occupancy-driven pharmacology), but also degraded (event-driven pharmacology). Hence, this strategy is characterized as a chemical knock-out. As a major advantage, only small drug doses are required since PROTACs act in a catalytic manner. SARS-CoV-2 and related coronaviruses induce the production of virus proteins in human cells. A highly important viral protein is the main protease, which is essential for viral replicatio...